Malaria has been extended - 1P45-Q1

1P45-Q1 a Malaria target has been extended into a larger set of molecules

Enoyl Reductase (ENR)

In Plasmodium falciparum (the parasite which causes Malaria), Enoyl Reductase (ENR) plays a critical role creating long chain molecules known as fatty acids which are used in the synthesis of cell wall mycolic acids. Effective inhibition of this enzyme has been demonstrated to have therapeutic potential in the treatment of Malaria.

Inhibiting Enoyl Reductase in Mycobacterium tuberculosis would also be effective against drug resistant strains of TB.

Pictures M R Kuo et al J Biol Chem (2003) 278.23 p20851-20859