New Targets

2 new targets available


Cancer
1NKP-Q2
MYC-MAX transcription factor

MYC-MAX transcription factor determines whether a cell will divide and proliferate. Deregulation of MYC has been implicated in the development of many human cancers, including Burkitt's lymphoma, neuroblastomas, and small cell lung cancers. An effective transcription inhibitor may have therapeutic potential in cancer.

In test jobs, the time taken was typical with fewer hits than usual.


G S Sheppard et al Bioorg Med Chem Lett (2004) 14.4 p865-8




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Respiratory Diseases
1BKC-Q1
TNF-alpha


The name Tumor necrosis factor-a (TNF-alpha) originates from its ability to kill tumor cells. It is a cytokine that induces protective inflammatory reactions but also causes severe damage when produced in excess, as in rheumatoid arthritis and septic shock. Our interest is in respiratory disease where it is also a recognised potential drug target. In test jobs, this query gave more hits than usual in typical times.


K Maskos et al Proc Natl Acad Sci (1998) 95.7 p3408-12