New Query - Cancer - 1C4Z-Q1

Cancer
1C4Z-Q1
E6AP ubiquitin-protein ligase

The E6AP ubiquitin-protein ligase (E3) mediates the human papillomavirus-induced degradation of the p53 tumor suppressor in cervical cancer. Inhibiting this interaction may be therapeutically useful preventing and treating cervical cancer.

Test jobs ran faster than average jobs giving few hits.


L Huang et al Science (1999) Nov 286 p1321-6



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Science Magazine article
Structure of an E6AP-UbcH7 Complex: Insights into Ubiquitination by the E2-E3 Enzyme Cascade
Lan Huang, Elspeth Kinnucan, Guangli Wang, Sylvie Beaudenon, Peter M. Howley, Jon M. Huibregtse, and Nikola P. PavletichScience Nov 12 1999: 1321-1326.