New Proteome Target - 1PTZ-Q1

Proteome
1PTZ-Q1
Superoxide dismutase

Mutations in Superoxide dismutase (SOD) have been associated with Lou Gehrig's disease (also known as ALS) which is the most common form of motor neuron disease. When neurons in the spinal cord die this leads to muscle wasting and total paralysis. For an inhibitor to have any therpeutic value it would need to selectively inhibit mutant SOD.

The time taken by test jobs varied greatly often taking longer than typical jobs giving above average numbers of hits.


D DiDonato et al J Mol Biol (2003) 334.1 p175