Tuberculosis - 1W2G-Q1 - Thymidylate Kinase (TMPK)

Respiratory Diseases
1W2G-Q1
Thymidylate Kinase ( TMPK )

This kinase converts thymidine monophosphate (TMP) to the di- and tri-phosphates. Inhibiting this process would be expected to significantly disrupt the cell cycle (ie growth). There is sufficient variation from the mammalian form and that found in mycobacterium tuberculosis to give scope for selective inhibition. This query is based a different crystal structure to 1g3u-q1.

In test jobs, this query took less time than typical jobs and gave below average numbers of hits.


I Li de la Sierra et al J Mol Biol (2001) 311 p87-100