Alzheimers - 1QKM-Q1 - Estrogen-β Receptor

Proteome
1QKM-Q1
Estrogen-β receptor

The estrogen receptor belongs to the family of Nuclear Receptors which trigger protein synthesis (via DNA transcription). It has been suggested that stimulating the Estrogen-β receptor in the brain might be therapeutically useful in the treatment of Alzheimer's disease. Inhibiting the Estrogen-α ligand binding domain is thought to have potential in cancer therapy (see 1sj0-q1).

This query gave more hits than typical jobs with jobs taking longer than average.


L Zhao and R D Brinton, J Med Chem (2005) 48.10 3463-6