Malaria - 1LS5-Q2 - Range extended

Plasmepsin IV, 1LS5-Q2 a Malaria target has been exteneded, initialy starting with jobs in the range 1550 to 19154.

Plasmodium falciparum (the parasite which causes Malaria) invades erythrocyte cells and consumes the host hemoglobin. Plasmepsin plays a key role digesting the protein and has been recognised as a novel target for anti-malaria drugs. Inhibition of hemoglobin degradation lead to toxic concentrations and parasite death in culture.