Cancer - 1YCQ-Q1 - Human Double Minute 2 (HDM2) bound to p53

Cancer
1YCQ-Q1
Human Double Minute 2 (HDM2) bound to p53

The p53 tumour suppressor protein regulates cell proliferation in cancer tumours. The binding of HDM2 to p53 has been observed to inhibit the action of p53 in one-third of soft tissue sarcomas. A small drug molecule which can binding to HDM2 would offer a novel cancer therpy with the potential to enable p53 to stop growth or kill the cancer cells.
This query is based on a different crystal structure to 1ycr-q3.

Test jobs for this query gave above average numbers of hits with longer job times.


P H Kussie et al Science (1996) 274 p921-2.