Methodology - 1M17-Q3 - Prediction Improvement

Methodology
1M17-Q3
Epidermal growth factor receptor

Two-thirds of solid tumors arise from epithelial tissues, and studies suggest that EGFR inhibitors can stabilize or shrink many of these malignancies. It is conceivable that EGFR inhibitors could beneficial in therapies for cancers of the lung, pancreas, head and neck, breast, prostate, colon, stomach, ovaries, and brain. However, the initial inhibitors in clinicals trials where less successful than expected. In this project, we hope to find more effective molecules.

This query is a variation of 1m17-q2 which we hope will give more and better hits. Job times will be longer than 1m17-q2.


J Stamos, M X Sliwkowski and C Eigenbrot J Biol Chem (2002) Vol 277 p46265