New Query - Proteome - 1W7H-Q1 - Inflammation

Proteome
1W7H-Q1
P38 MAP kinase

This protein plays a crucial role in regulating the production of proinflammatory signalling molecules of the immune system. Consequently, blocking the function of this kinase using a small molecule inhibitor has potential as an effective therapy for treating a wide range of inflammatory diseases. This query is based on a different crystal structure to 1kv2.

The job times vary but take about 10 hours on average on a typical PC giving more than typical numbers of hits.


C Pargellis et al, Nat. Struct. Biol. (2002) 9.4 p268-72