Arthritis - 1FX9-Q1 - Phospholipase A2 (PLA2)

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1FX9-Q1
Phospholipase A2 ( PLA2 )

Phospholipase A2 (PLA2) cleaves ester bond in glycerophospholipids releasing free fatty acids and lysophospholipids. Excessive levels of human nonpancreatic PLA2 has been associated with a number of disease states including arthritis, septic shock and atherosclerosis. Inhibition of PLA2 may have therapeutic potential in the treatment of arthritis.

Job times for this query took longer than typical jobs giving above average numbers of hits.

J S Sawyer et al J Med Chem (2005) 48.3 p893-6