Cancer - 1L2I-Q1 - Estrogen-α Receptor

Cancer
1L2I-Q1
Estrogen-α Receptor

The estrogen receptor belongs to the family of Nuclear Receptors which trigger protein synthesis (via DNA transcription). Hormones bind to the ligand binding domain facilitating the DNA to interact with another domain. Inhibiting the Estrogen ligand binding domain is thought to have potential in cancer therapy. This query is based on a different crystal structure to 1sj0-q1 and 1uom-q1.

This query gave more hits than typical jobs with jobs taking longer than average.

S Kim et al, J Med Chem (2004) 47.9 p2171-5