HIV - 1RQL-Q1 - Deoxyhypusine Synthase

HIV
1RQL-Q1
Deoxyhypusine Synthase

Inhibiting this enzyme suppresses hypusine formation and the activation of a cofactor in the HIV-1 Rev regulatory protein. This inhibits the replication of the virus. It has been suggested that this is an attractive drug target because few side-effects are anticipated and especially useful for strains of HIV resistant to other drugs. This query is based a different protein crystal structure to 1dhs-q1.

The time taken by our test jobs was variable with some jobs taking longer than typical jobs but mostly giving fewer hits.

D I Liao et al, Structure (1998) 6 p23