The End

Well due to popular demand the automatic uninstallation was left a little longer to finish off the last query. Since that has finished, Uninstall will be automatically started the next time the client connects to Find-a-Drug as of the time of writing


Look out in the new year for a release of new certificates found to exhibit anti-??? activity.

Sousaphone + Supermarket = Delays

The auto-uninstalling of Find-a-Drug clients will be delayed due to a Sousaphone and a Supermarket


So the widspread uninstallation of the clients will be delayed until Monday 19th 2005(UK)

Alzheimer/Parkinson/Stroke - 1PMQ-Q1 - c-Jun N-terminal kinases (JNKs)

Proteome
1PMQ-Q1
c-Jun N-terminal kinases (JNKs)

c-Jun N-terminal kinases (JNKs) is a mitogen-activated protein kinase (MAPK) and JNK-3 is primarily found in certain nerve cells where is it plays a role in cell death. It has been identified as an attracive therapeutic target in Neurological disorders - especially Alzheimer's disease and Parkinson's disease. It has also been suggested that inhibitors to JNK-3 might be beneficial to stroke victims. This query is based on a different crystal structure to 1PMN-Q1.

Test jobs for this query gave average numbers of hits with many jobs completing in less time than typical jobs.? Description

L Resnick & M Fennell DDT (2004) 9.21 p932-939

Virus/Cancer - 1I3Z-Q1 - EWS/FLT1 Activated Transcript 2 (EAT-2)

Proteome
1I3Z-Q1
EWS/FLT1 Activated Transcript 2 ( EAT-2 )

The immune system produces Natural Killer (NK) cells in response to most virus infections and cancer tumours. EWS/FLT1 Activated Transcript 2 (EAT-2) suppresses the killer function and it has been suggested that a small molecule which inhibited EAT-2 might have therapeutic potential.

The job times for test queries varied often taking longer average jobs and giving more hits.

R Roncagalli et al Immunology (2005) 6 p 1002-1010

Cancer - 1I4O-Q1 - X-linked Inhibitor of Apoptosis Protein (XIAP)

Cancer
1I4O-Q1
X-linked Inhibitor of Apoptosis Protein (XIAP)

Inhibitor of Apoptosis proteins are often present in exceptionally high quantities in cancer tissues. It is believed that molecules which bind to X-linked Inhibitor of Apoptosis Protein (XIAP) induce cell death by freeing caspases.

The job times for test queries varied with most giving typical numbers of hits.

K Thorsten et al J Med Chem (2004) 47.18 p4417-26

Cancer - 1M2G-Q1 - Silent information regulator 2 (Sir2)

Cancer
1M2G-Q1
Silent information regulator 2 ( Sir2 )

Silent information regulator 2 (Sir2) can deactivate p53 (a tumour suppressor protein) which is undesirable in tumours. Sir2 inhibitors have potential as novel anti-cancer drugs.

The times for test jobs were longer than average giving more hits.

J Posakony et al J Med Chem (2004) 47.10 p 2635-44

Testing Auto-Uninstall Procedure

The beta testing of the Auto-uninstalation procedure has started today

It is anticipated that the software will automatically uninstall when the project closes on 16 December. In practice, this means that when a PC attempts to download jobs after the 16 December a new version of loader will be downloaded which will run automatically an uninstall the software.

To test this

1. Take a backup of the Find-a-Drug software folder including its cache subfolder. It may be a good idea to stop think before doing so and restart the software afterwards (ie run loader).

2. Download http://www.find-a-drug.net/uninstal/loader.exe for Windows or http://www.find-a-drug.net/uninstal/loader for Linux. Under Linux you will need to use chmod to make loader executable (chmod u+x loader). You must move loader to the folder containing the software!

3. Manually run loader.exe (windows) or loader (Linux)




This should:

1. Stop the software.

2. Remove think.lgo from startup folders and any service definitions created by 1.30 beta.

3. Remove Find-a-Drug Control Panel desktop icon and Find-a-Drug items under Start > Programs

4. Delete most of the contents of the software folder and cache subfolder (loader.exe and salflibc.dll are deliberately left behind under Windows just incase a non-standard startup procedure is being used). jobs.htm is also left behind. Depending on the version of THINK you originally installed and which (if any) test versions you ran there may be a few other files left.




We are aware that

1. Any non-standard startup procedure which references think.exe or fadsetup.exe will fail as these files have been removed.

2. 1.25 Linux users will probably see error message 26 relating to writing to computer.tlg. This can be ignored.

3. Registry entries are left behind - just incase they are useful in the future.

You should be able to restore the backup and continue processing the remaining queries after you have completed the test.

Diabetes/Obesity - 2SHP-Q2 - Tyrosine phosphatase SHP-2

Proteome
2SHP-Q2
Tyrosine phosphatase SHP-2

The molecular signalling associated with Diabetes and Obesity is complicated and not fully understand. Tyrosine phosphatase SHP-2 plays a role in this and it has been suggested that it may be an appropriate drug target.

Most test jobs took longer than average jobs and gave more hits.

P Hof et al, Cell (1998) 92 p 441-450

Cancer - 1JD4-Q1- Transcription Factor 4 (TCF4)

Cancer
1JD4-Q1
Transcription Factor 4 ( TCF4 )

Transcription Factor 4 (TCF4) is a known to interact with beta-catenin in several different ways. It is a recognised anti-cancer target although side-effects and selectivity are likely to be problematic.

The job times for test queries where typical often giving more hits.


J W Wu et al Mol Cell (2001) 8 p95-104