Alzheimer/Parkinson/Stroke - 1PMQ-Q1 - c-Jun N-terminal kinases (JNKs)

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1PMQ-Q1
c-Jun N-terminal kinases (JNKs)

c-Jun N-terminal kinases (JNKs) is a mitogen-activated protein kinase (MAPK) and JNK-3 is primarily found in certain nerve cells where is it plays a role in cell death. It has been identified as an attracive therapeutic target in Neurological disorders - especially Alzheimer's disease and Parkinson's disease. It has also been suggested that inhibitors to JNK-3 might be beneficial to stroke victims. This query is based on a different crystal structure to 1PMN-Q1.

Test jobs for this query gave average numbers of hits with many jobs completing in less time than typical jobs.? Description

L Resnick & M Fennell DDT (2004) 9.21 p932-939