Cancer - 1M2G-Q1 - Silent information regulator 2 (Sir2)

Cancer
1M2G-Q1
Silent information regulator 2 ( Sir2 )

Silent information regulator 2 (Sir2) can deactivate p53 (a tumour suppressor protein) which is undesirable in tumours. Sir2 inhibitors have potential as novel anti-cancer drugs.

The times for test jobs were longer than average giving more hits.

J Posakony et al J Med Chem (2004) 47.10 p 2635-44