New Queries - Proteome & Cancer

Proteome
1DVY-Q3
Transthyretin

The human amyloid disorders (including polyneuropathy, cardiomyopathy and senile amyloidosis) are caused by insoluble transthyretin (TTR) fibrils being deposited in the peripheral nerves and heart tissue. It has been suggested that inhibiting TTR may have therapeutic value by stopping the formation of such fibrils.

Test jobs gave below average numbers of hits in less time than typical.


T Klabunde et al Nat Struct Biol (2000) 7.4 p312-21.






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Cancer
1SJ0-Q1
Estrogen receptor

The estrogen receptor belongs to the family of Nuclear Receptors which trigger protein synthesis (via DNA transcription). Hormones bind to the ligand binding domain facilitating the DNA to interact with another domain. Inhibiting the Estrogen ligand binding domain is thought to have potential in cancer therapy


S Kim et al, J Med Chem (2004) 47.9 p2171-5

Interesting article
Suggestions it may also valuable for lung cancer as well as cancers of the breast, uterus and ovaries