Malaria - 1BZY-Q1 - Hgprtase

Malaria
1BZY-Q1
Hgprtase

Hypoxanthine-Guanine Phosphoribosyltransferase (Hgprtase) is important as a source of purine to Plasmodium falciparum (the parasite which causes Malaria). This is because the parasite is unable to make its own purine. It has been suggested that inhibiting this enzyme may be therapeutically valuable. This query is based on a different crystal structure to 1d6n-q1.

In test jobs, this query gave more hits than usual with variable times.


G K Balendiran et al, Protein Sci (1999) 8.5 p1023