Multiple Sclerosis - 1PKQ-Q4 - Myelin Oligodendrocyte Glycoprotein

Multiple Sclerosis
1PKQ-Q4
Myelin Oligodendrocyte Glycoprotein

Multiple sclerosis is a chronic disease of the central nervous system (CNS) characterized by inflammation, demyelination, and nerve axon loss. The immune response is responsible for the degradation of the protective myelin sheath around the spinal cord. This involves an autoantibody response to myelin oligodendrocyte glycoprotein (MOG) located at the surface of CNS myelin. This is the third of a short series of queries where we seek small molecules which might inhibit the immune responsible which would halt the progress of the disease. The series target different sites of the same protein.

Test jobs for this query took less time than typical jobs giving few hits.


C Breithaupt et al Proc Nat Acad Sci (2003) 100 p9446