Cancer - 1T46-Q1 - c-Kit Tyrosine Kinase

Cancer
1T46-Q1
c-Kit Tyrosine Kinase

c-Kit Tyrosine Kinase is a transmembrane protein that initiates cell growth signalling. Mutations of c-Kit can result in over-stimulation when the natural regulation fails. This has been observed in gastrointestinal stromal tumors, germ cell tumors, mast cell and myeloid leukemias, and in mastocytosis. An inhibitor might be useful therapeutically for a range of different cancers.

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C D Mol et al, J Biol Chem (2004) 279.30 p31655-63