Cancer - 1U59-Q1 - ZAP-70 (SYK-related) Tyrosine Kinase

Cancer
1U59-Q1
ZAP-70 (SYK-related) Tyrosine Kinase

Many Tyrosine Kinases including SYK are inhibited by some anti-cancer drugs. Tyrosine Kinases are also associated with rheumatoid arthritis, inflammation and immunological responses. A lack of selectivity might cause undesirable side-effects and prohibit long term use as preventative treatment.

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L Jin et al J Biol Chem (2004) 279 p42818