Proteome - 1QTN-Q1 - neurodegenerative diseases, stroke

Proteome
1QTN-Q1
Caspase-3

Caspases play a key role in inflammation and apoptosis (cell death). Inhibition of this enzyme would be expected to prolong cell-life. In some neurodegenerative diseases, neuron death is associated with progression of the disease and a caspase-8 inhibitor might be therapeutically useful. Such a therapy may also be of benefit to stroke victims.

This query gave above average numbers of hits in test jobs taking longer than average.

W Watt et al, Structure (1999) 7 p1135