Methodology - 1E7U-Q4 - Better Hits Included or Not / Cancer

Methodology
1E7U-Q4
Phosphatidylinositol 3 Kinase

Phosphatidylinositol 3 Kinase (PI3K) regulation of the Akt/PKB pathway is essential for cell survival. Inhibition of PI3K leads to apoptosis (cell death) as a consequence Akt/PKB not phosphorylating proteins including Bad, transcription factors, caspase-9 amd ASK-1. There is reason for thinking that cancer cells would be selectively killed by a PI3K inhibitor.

This query is part of a series which explores the use of less stringent queries that give more hits. We hope to gain an insight into whether better hits are generally included. Test jobs for this query took longer and gave more hits than typical jobs.

E H Walker et al (2000) Mol Cell Biol 6 p909