New Query - Methodology - 1EL3-Q2

Methodology
1EL3-Q2
Aldose Reductase

In general, a drug which in addition to its intended action interferes with the normal metabolic processing or signalling is likely to exhibit side-effects. It has also been suggested that Aldose Reductase can mediates certain diabetic complications such as hyperglycemia; metabolises toxic aldehydes; and stimulates an inflammation response.

In test jobs, this query gave more hits than usual taking less time than typical jobs.


V Calderone et al, Acta Cryst D (2000) 56 p536-40