Malaria - 1LS5-Q2 - Plasmepsin IV

Malaria
1LS5-Q2
Plasmepsin IV

Plasmodium falciparum (the parasite which causes Malaria) invades erythrocyte cells and consumes the host hemoglobin. Plasmepsin plays a key role digesting the protein and has been recognised as a novel target for anti-malaria drugs. Inhibition of hemoglobin degradation lead to toxic concentrations and parasite death in culture. This query is based on a different crystal structures to 1lf2-q1 and 1lee-q1.

We expect jobs for this query to give more than typical numbers of hits in average times.



O A Asojo et al Acta Cryst (2002) d58 p2001