Arthritis - 1FDK-Q1 - Phospholipase A2 (PLA2)

Proteome
1FDK-Q1
Phospholipase A2 ( PLA2 )

Phospholipase A2 (PLA2) cleaves ester bond in glycerophospholipids releasing free fatty acids and lysophospholipids. Excessive levels of human nonpancreatic PLA2 has been associated with a number of disease states including arthritis, septic shock and atherosclerosis. Inhibition of PLA2 may have therapeutic potential in the treatment of arthritis. This query is based on a different crystal structure to 1fx9-q1.

Job times for this query are variable with some jobs taking less time than usual and giving very few hits.

J S Sawyer et al J Med Chem (2005) 48.3 p893-6