Arthritis - 1FXF-Q1 - Phospholipase A2 (PLA2)

Proteome
1FXF-Q1
Phospholipase A2 (PLA2)

Phospholipase A2 (PLA2) cleaves ester bond in glycerophospholipids releasing free fatty acids and lysophospholipids. Excessive levels of human nonpancreatic PLA2 has been associated with a number of disease states including arthritis, septic shock and atherosclerosis. Inhibition of PLA2 may have therapeutic potential in the treatment of arthritis. This query is based on a different crystal structure than 1fx9-q1.

For test jobs, times and numbers of hits for this query where typical.


J S Sawyer et al J Med Chem (2005) 48.3 p893-6