Tuberculosis - 1RRI-Q1 - 7,8-Dihydroneopterin Aldolase

Respiratory Diseases
1RRI-Q1
7,8-Dihydroneopterin Aldolase

7,8-Dihydroneopterin Aldolase ( DHNA ) has no human equivalent but is an essential enzyme in bacteria including Mycobacterium Tuberculosis, playing a critical role in folate synthesis. This is a novel antibacterial target which is interesting because bacteria in contrast to humans (and other mammals) cannot absorb folate from their environment. Without folate bacteria cannot grow! This query is based on a different crystal structure to 1nbu-q1.

This query gives above average number of hits and longer than typical job times.


W J Sanders et al J Med Chem (2004) 47.7 p1709-18